PESQUISA VETERINÁRIA BRASILEIRA

Abstract in English:

ABSTRACT.- Milori F.P., Prado A.M.R.B., Quitzan J., Souza R.S., Cirio S.M. & Dornbusch P.T. 2013. [Bone plates produced from equine cortical bone in rabbits femoral osteosynthesis.] Placas ósseas confeccionadas a partir de diáfise cortical equina na osteossíntese femoral em coelhos. Pesquisa Veterinária Brasileira 33(10):1201-1207, Programa de Pós-Graduação em Ciência Animal, Escola de Ciências Agrárias e Medicina Veterinária, Pontifícia Universidade Católica do Paraná, Campus II, Rodov. BR-376 Km 14, Cx. Postal 129, São José dos Pinhais, PR 83010-500, Brazil. E-mail: fernandomilori@yahoo.com.br Actually, technological advances have contributed to the development and improvement of new materials for implants. Despite the fundamental benefits provided by orthopedic materials, complications resulting from corrosion, degradation, infection, and others may occur. The knowledge of characteristics of the biomaterials is important to predict their behavior in vivo, supporting that the most suitable compound is chosen to reconstruct the bone defect. Metallic plates are the most common material used for repair of long bone fractures, and they are mechanically stable and biocompatible. However, the need of removal and bone weakening are their disadvantages. In this paper, plates made from equine cortical bone were used experimentally in osteotomized rabbit femur (bone-GO Group), in a comparative study with metal plates (metal GM Group). Radiographic evaluation was performed every 30 days during 120 days, at which time was then performed femur histological analysis. During all evaluated moments of the study, there was no statistically significant difference between the two groups in callus morphometry, and complete consolidation was observed in all animals. However, it was observed that the callus was lower in GO compared to GM, all times during the study. Moreover, most of the GO animals showed complete consolidation fracture at 90 days only, whereas this occurred in GM at 60 days. There were no foreign-body cells in the histopathology exam of the GO animals, but larger amount of fibrous tissue was identified, involving this biomaterial. The plate made from horse bone represents a low cost alternative and it is very feasible, it allowed adequate stabilization of femur fracture in rabbits. In this study, the lower periosteal callus associated with a longer time for consolidation in GO suggest greater fracture stability when the bone plate was used.

• Orthopedicplate ortopedia

Abstract in Portuguese:

RESUMO.- Milori F.P., Prado A.M.R.B., Quitzan J., Souza R.S., Cirio S.M. & Dornbusch P.T. 2013. [Bone plates produced from equine cortical bone in rabbits femoral osteosynthesis.] Placas ósseas confeccionadas a partir de diáfise cortical equina na osteossíntese femoral em coelhos. Pesquisa Veterinária Brasileira 33(10):1201-1207, Programa de Pós-Graduação em Ciência Animal, Escola de Ciências Agrárias e Medicina Veterinária, Pontifícia Universidade Católica do Paraná, Campus II, Rodov. BR-376 Km 14, Cx. Postal 129, São José dos Pinhais, PR 83010-500, Brazil. E-mail: fernandomilori@yahoo.com.br A evolução tecnológica tem possibilitado o desenvolvimento e o aperfeiçoamento de novos materiais para implantes. Apesar dos fundamentais benefícios providos pelos dispositivos ortopédicos, complicações decorrentes de corrosão, degradação, infecção, além de outras podem ocorrer. O entendimento das características dos biomateriais é fundamental para a previsibilidade do seu comportamento in vivo, fornecendo subsídios para que o composto mais adequado seja escolhido na reconstrução do defeito ósseo. As placas de origem metálica são as mais utilizadas para o reparo de fraturas de ossos longos, sendo mecanicamente resistentes e biocompatíveis. No entanto, a necessidade de remoção e o enfraquecimento do osso são suas principais desvantagens. Neste trabalho, placas produzidas a partir de osso cortical equino foram empregadas experimentalmente em fêmur osteotomizado de coelhos (Grupo osso-GO), num estudo comparativo com placas de metal (Grupo metal-GM). A avaliação radiográfica foi realizada a cada 30 dias, durante 120 dias, momento em que foi então realizada análise histológica do material em estudo. Não houve diferença estatisticamente significante entre os dois grupos com relação à morfometria do calo ósseo e consolidação óssea em todos os momentos avaliados, sendo que ambas as placas permitiram a consolidação em todos os animais. Entretanto, observou-se que o calo ósseo foi menor no GO, em relação ao GM, em todos os momentos do estudo. Por outro lado, a maior parte dos animais do GO apresentou consolidação completa da fratura aos 90 dias, enquanto que no GM isto ocorreu aos 60 dias. Não foram evidenciadas células do tipo corpo estranho na histopatologia dos animais do GO, mas maior quantidade de tecido fibroso foi identificada, envolvendo este biomaterial. A placa confeccionada com osso equino representa uma alternativa de baixo custo e muito viável, uma vez que permitiu estabilização adequada para consolidação óssea de fratura de fêmur em coelhos. Neste estudo, a menor formação de calo periosteal, associada a um tempo superior para consolidação em GO sugerem maior estabilidade da fratura onde a placa de osso foi utilizada.

Abstract in English:

ABSTRACT.- Hussni C.A., Dornbusch P.T., Yoshida W.B., Alves A.L.G., Nicolett, J.L.M., Mamprim M.J. & Vulcano L.C. 2009. [Thrombectomy with Fogarty’s catheter as a treatment of induced jugular thrombophlebitis in horses.] Trombectomia com cateter de Fogarty no tratamento da tromboflebite jugular experimental em eqüinos. Pesquisa Veterinária Brasileira 29(1):45-51. Departamento de Cirurgia e Anestesiologia Veterinária, Faculdade de Medicina Veterinária e Zootecnia, Universidade Estadual Paulista, Botucatu, SP 18618-000, Brazil. E-mail: cahussni@fmvz.unesp.br Thrombosis of jugular vein is a common problem in the equine medicine, implying frequently in fatal outcomes. The diagnosis is relatively simple, based on the clinical findings, angiographics images and ultrasonographycs. The therapeutic employed to a large extent of the cases is unsatisfactory. The purpose of this study was to evaluate the applicability of the thrombectomy with Fogarty’s catheter in horses. This technique is routinely used in medicine, in the reestablishment of the vascular perviousness. Ten horses were allocated in two groups (five animals each) and induced to an unilateral thrombosis of right jugular vein, through the surgical access and an application of stenotic suture and glucose 50% injection. In the control group evolution of the thrombophlebitis without any therapeutical intervention was evaluated. The animals of the treatment group were submitted to the thrombectomy with Fogarty’s catheter. General clinical parameters were analyzed at the moment of the preinduction (MPRE), induction of thrombosis (MTI), and at the 10th day of thrombosis evolution (M10). The procedure induced thrombophlebitis that completely obstructed a segment of the jugular vein in all animals. In the animals of the control group, the thrombus totally obstructed the vascular lumen until the end of the period of evaluation, and parotid edema and vascular dilated, cranial to the thrombophlebitis of jugular vein were observed. The treatment group presented all veins pervious in the end of the experiment, with total remission of the clinical signs, confirmed by angiographic and ultrasonographic examinations. So far, it was concluded that the technique of thrombectomy with Fogarty’s catheter was effective in removal of the thrombosis obstruction experimentally induced in the jugular vein.

• Horses jugular vein thrombophlebitis thrombectomy Fogarty’s catheter

Abstract in Portuguese:

ABSTRACT.- Hussni C.A., Dornbusch P.T., Yoshida W.B., Alves A.L.G., Nicolett, J.L.M., Mamprim M.J. & Vulcano L.C. 2009. [Thrombectomy with Fogarty’s catheter as a treatment of induced jugular thrombophlebitis in horses.] Trombectomia com cateter de Fogarty no tratamento da tromboflebite jugular experimental em eqüinos. Pesquisa Veterinária Brasileira 29(1):45-51. Departamento de Cirurgia e Anestesiologia Veterinária, Faculdade de Medicina Veterinária e Zootecnia, Universidade Estadual Paulista, Botucatu, SP 18618-000, Brazil. E-mail: cahussni@fmvz.unesp.br Thrombosis of jugular vein is a common problem in the equine medicine, implying frequently in fatal outcomes. The diagnosis is relatively simple, based on the clinical findings, angiographics images and ultrasonographycs. The therapeutic employed to a large extent of the cases is unsatisfactory. The purpose of this study was to evaluate the applicability of the thrombectomy with Fogarty’s catheter in horses. This technique is routinely used in medicine, in the reestablishment of the vascular perviousness. Ten horses were allocated in two groups (five animals each) and induced to an unilateral thrombosis of right jugular vein, through the surgical access and an application of stenotic suture and glucose 50% injection. In the control group evolution of the thrombophlebitis without any therapeutical intervention was evaluated. The animals of the treatment group were submitted to the thrombectomy with Fogarty’s catheter. General clinical parameters were analyzed at the moment of the preinduction (MPRE), induction of thrombosis (MTI), and at the 10th day of thrombosis evolution (M10). The procedure induced thrombophlebitis that completely obstructed a segment of the jugular vein in all animals. In the animals of the control group, the thrombus totally obstructed the vascular lumen until the end of the period of evaluation, and parotid edema and vascular dilated, cranial to the thrombophlebitis of jugular vein were observed. The treatment group presented all veins pervious in the end of the experiment, with total remission of the clinical signs, confirmed by angiographic and ultrasonographic examinations. So far, it was concluded that the technique of thrombectomy with Fogarty’s catheter was effective in removal of the thrombosis obstruction experimentally induced in the jugular vein.